Evaluation of solid carvedilol-loaded SMEDDS produced by the spray drying method and a study of related substances

In this study, various formulations of solidified carvedilol-loaded SMEDDS with high loading (up to 67% w/w) were produced the spray drying process using porous silica-based carriers. The yield was improved higher atomization gas flow rate during and prolonged mixing time dispersion liquid solid carriers prior process. Depending on choice carrier SMEDDS:carrier ratio in SMEDDS, different drug loading, self-microemulsifying properties, release rates, released fractions obtained. products exhibited fast due preserved properties absence crystalline carvedilol, which confirmed XRD Raman mapping. A decrease content stability study observed investigated. This at least partially attributed chemical degradation drug. Key determined by LC-MS method amides formed situ reaction carvedilol fatty acids present oily phase SMEDDS.